Spirulina scientific reference library. Over 100 references covering 45 years of international research.
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Effects of Spirulina platensis microalgae on antioxidant and anti-inflammatory factors in diabetic rats. by Fariba Nasirian et al. Pub. in Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. Aug 2018. Iran.
Objectives: Lipid peroxidation and hyperglycemia are common signs for diabetes. Natural antioxidants such as Spirulina platensis microalgae (SPM) may prevent lipid peroxidation and hyperglycemia. This study aimed to evaluate the effects of SPM on antioxidant and anti-inflammatory in diabetic rats.
Conclusion: It can be concluded that diabetes decreases TM concentration and antioxidant enzymes and also increases lipid profile, glucose, AST, ALT, TNF-α and IL-6 concentrations. Inclusion of SPM supplementing (20 and 30 mg/kg body weight) increased some TMs and antioxidant enzymes. SPM may provide TMs for synthesis of antioxidant enzymes which sub-sequently reduce lipid profile, glucose concentration and anti-inflammatory responses.

Effect of water soluble and water insoluble fractions of spirulina over serum lipids and glucose resistance of rats.
by Y. Takai, et al. 1991. Pub. in J. Japan Soc. Nutr. Food Science, 44:273-277. Japan.

Effects of spirulina on plasma lipoprotein lipase activity in rats.
by K. Iwata, et al. 1990. Pub. ?in Journal Nutr. Sci. Vitaminol, 36:165-171. Japan.

The effects of spirulina on lipoprotein lipase activity and hepatic triglyceride lipase activity in post-heparin plasma were studied in fructose-induced hyperlipidemic rats. Male Wistar rats aged 3 weeks old (body weight, 54g) were fed on the high-fructose diet (68%) or the high-fructose diets containing spirulina at the level of 5%, 10%, and 15%, respectively, for 4 weeks. The dietary hyperlipidemia caused by the high-fructose diet was improved by spirulina feeding, accompanied by a significant increase in the lipoprotein lipase activity in post-heparin plasma.