The effects of spirulina on lipoprotein lipase activity and hepatic triglyceride lipase activity in post-heparin plasma were studied in fructose-induced hyperlipidemic rats. Male Wistar rats aged 3 weeks old (body weight, 54g) were fed on the high-fructose diet (68%) or the high-fructose diets containing spirulina at the level of 5%, 10%, and 15%, respectively, for 4 weeks. The dietary hyperlipidemia caused by the high-fructose diet was improved by spirulina feeding, accompanied by a significant increase in the lipoprotein lipase activity in post-heparin plasma.